Spravato For Depression

Spravato For Depression

Depression is a serious mental illness that affects millions of people worldwide. Despite various traditional treatment options, not everyone responds to them, and the search for new, more effective treatments continues. One such treatment that has gained attention in recent years is Spravato. This article seeks to explore this emerging treatment for depression and its potential benefits.

Understanding Depression

Depression is a common mental health disorder that can cause severe symptoms affecting the way people feel, think, and behave. It is a complex disorder that can occur due to various factors such as genetics, life experiences, emotional trauma, and a chemical imbalance in the brain. Depression can lead to prolonged sadness, hopelessness, and a loss of interest in daily activities. It can also affect a person’s ability to work, study, and enjoy life.

Symptoms Of Depression

Depression can manifest itself in various ways, including:

  • Extended periods of sadness or irritability
  • Difficulty sleeping or sleeping more than usual
  • Loss of interest in activities that were once enjoyable
  • Feeling tired or lacking energy
  • Difficulty concentrating or making decisions
  • Changes in appetite or weight gain/loss

Not everyone experiences depression in the same way. Some people may have only a few symptoms, while others may have many. Additionally, the severity and duration of symptoms can vary from person to person.

Causes Of Depression

The cause of depression isn’t fully understood, but it is thought to be the result of a combination of genetic, biological, environmental, and psychological factors. For example, a family history of depression may increase a person’s risk of developing the disorder. Additionally, changes in brain chemistry, such as a decrease in serotonin levels, can contribute to the development of depression.

Life experiences can also play a role in the development of depression. Traumatic events, such

as the death of a loved one, a divorce, or a job loss, can trigger depression in some people. Additionally, chronic stress, social isolation, and a lack of support can increase a person’s risk of developing depression.

Traditional Treatment Options

There are various traditional treatment options for depression, including medication, psychotherapy, and electroconvulsive therapy (ECT), among others. Antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs), can help regulate brain chemistry and improve symptoms of depression.

Psychotherapy, such as cognitive-behavioral therapy (CBT), can help people identify and change negative thought patterns and behaviors that contribute to depression. Electroconvulsive therapy (ECT) is a procedure that uses an electric current to stimulate the brain and can be effective for severe cases of depression.

While these treatments can be effective, not everyone responds to them, and they may have significant side effects. Additionally, some people may prefer to try alternative or complementary therapies, such as exercise, meditation, or acupuncture, to manage their symptoms of depression.

It is essential to seek help if you or someone you know is experiencing symptoms of depression. Depression is a treatable condition, and with the right treatment, people can recover and lead fulfilling lives.

What Is Spravato?

Spravato is an FDA-approved nasal spray medication developed by Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson. It is a novel approach to treating depression as it uses a different mechanism of action compared to traditional antidepressants.

The Active Ingredient: Esketamine

The active ingredient in Spravato is esketamine, which is a derivative of ketamine, a well-known anesthetic drug. Esketamine works by blocking N-methyl-D-aspartate (NMDA) receptors in the brain, which are believed to play a role in depression. By blocking NMDA receptors, Spravato increases the amount of a neurotransmitter called glutamate, which is associated with positive mood and cognitive function.

How Spravato Differs From Ketamine

Spravato differs from ketamine in several ways. Firstly, Spravato uses esketamine instead of ketamine, which is believed to be more effective and cause fewer psychotomimetic effects, such as hallucinations, than ketamine. Secondly, Spravato is administered as a nasal spray, whereas ketamine is typically given via intravenous infusion.

Lastly, Spravato is available in a controlled, clinic-based setting, whereas ketamine is used off-label and is not FDA-approved for depression. Both Spravato and ketamine are only available through a prescription from a healthcare provider and should only be used under medical supervision.

FDA Approval & Availability

Spravato received FDA approval in March 2019, making it the first treatment for depression to be approved by the FDA in over 30 years. This was a significant milestone in the treatment of depression as it provided a new option for patients who have not responded to other treatments. Spravato is currently only available in a limited number of specially certified clinics and is approved for use in conjunction with an oral antidepressant for treatment-resistant depression.

Spravato is not a first-line treatment for depression and should only be used after other treatments have been tried and failed. It is also important to note that Spravato can have side effects, including sedation, dissociation, and an increase in blood pressure, and should only be used under the supervision of a healthcare provider.

How Spravato Works

The Science Behind Spravato

Studies have shown that esketamine, the active ingredient in Spravato, can rapidly reduce the symptoms of depression in individuals who have not responded to traditional treatments. In clinical trials, Spravato was found to be significantly more effective than placebo in reducing symptoms of depression. This is exciting news for those who have struggled with depression and have not found relief from other treatments.

Researchers are still working to fully understand how Spravato works. However, it is thought that the medication may work by targeting the NMDA receptors in the brain. These receptors are involved in a wide range of brain functions, including learning and memory. By blocking NMDA receptors, Spravato may alleviate depression symptoms and potentially address the underlying neurological mechanisms of depression.

Spravato’s Effect On Brain Function

Research has also shown that Spravato can affect brain function beyond its antidepressant effects. For example, it can induce new neural connections, improve memory consolidation and learning, and even reduce suicidal ideation. These findings suggest that Spravato may have broader applications beyond treating depression.

One study found that Spravato can enhance the formation of new neural connections in the brain. This process, known as neuroplasticity, is key for learning and memory. By promoting neuroplasticity, Spravato may help individuals with depression to learn new coping skills and strategies for managing their symptoms.

Another study found that Spravato can improve memory consolidation and learning. This is particularly vital for individuals who have experienced cognitive impairments as a result of depression. By improving memory function, Spravato may help these individuals to regain some of their cognitive abilities and improve their overall quality of life.

The Role Of NMDA Receptors

The exact role of NMDA receptors in depression is not fully understood, but there is growing evidence that they play a significant role in the disorder. By blocking NMDA receptors, Spravato may alleviate depression symptoms and potentially address the underlying neurological mechanisms of depression.

Research has shown that individuals with depression may have altered NMDA receptor function. By targeting these receptors, Spravato may help to restore normal receptor function and alleviate depression symptoms. This is an exciting area of research, as it may lead to the development of new treatments for depression that target the underlying neurological mechanisms of the disorder.

Spravato Treatment Process

Initial Consultation & Assessment

Prior to starting Spravato treatment, a clinician will assess the patient’s medical history, current medication use, and other factors to determine if Spravato is an appropriate treatment option. The clinician may also discuss any potential side effects and risks associated with the medication.

It is important for the patient to be honest and transparent during the initial consultation and assessment process. This will help the clinician make an informed decision about whether or not Spravato is the right treatment option. Patients should also feel free to ask any questions they may have about the medication or the treatment process.

The Spravato Administration Process

During treatment, Spravato is administered as a nasal spray once or twice a week, depending on the patient’s response. The clinician will supervise the administration of the medication to ensure the patient’s safety.

The actual administration of the medication is a quick and painless process. The patient will simply need to tilt their head back slightly and the clinician will administer the nasal spray. The patient may experience a slight burning or numbing sensation in their nose, but this is normal and should subside quickly.

After administration, the patient will need to remain under observation for at least two hours to monitor for potential side effects. During this time, the patient may feel drowsy or disoriented, so it is crucial for them to have someone to drive them home afterwards.

Monitoring & Follow-Up Appointments

Following treatment, the clinician will monitor the patient’s progress and adjust the treatment plan if necessary. The clinician may also recommend psychotherapy or other adjunct treatments to support the patient’s recovery.

It is critical for patients to attend all follow-up appointments and to communicate any concerns or issues they may be experiencing. This will help the clinician make informed decisions about the patient’s treatment plan and ensure the best possible outcome.


Spravato represents a novel approach to treating depression that may offer hope to individuals who have not responded to traditional treatments. While it is not without risks, Spravato’s unique mechanism of action opens up the possibility for new treatment options and a better understanding of the underlying neurological mechanisms of depression.

Contact Revitalizing Infusion Therapies today to learn how our Spravato treatment can help you on the road to recovery!

If you are interested in learning more about ketamine for depression treatment in Kissimmee, FL, contact Revitalizing Infusion Therapies and request your consultation today.


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