IV Esketamine, Ketamine Equally Effective for Resistant Depression

Woman with Depression with RIT logo

Intravenous (IV) esketamine is as safe and effective as IV ketamine for patients with treatment-resistant depression, new research suggests. “Our study was the first randomized clinical trial directly comparing ketamine and esketamine in treatment-resistant depression,” senior investigator Lucas C. Quarantini, MD, PhD, Division of Psychiatry.

Why Does Ketamine Work for Depression When Nothing Else Does?

Man in business attire looking depressed

Even though depression is a common and debilitating mental illness, the last groundbreaking medication released for it was Prozac, approved in 1987. Throughout the last 20 years, though, research scientists have discovered that ketamine, a common anesthetic and, at times, a recreational drug, is a rapid and effective medication for treatment-resistant depression. As we’re learning […]

The Role of Sleep and Reward Processing in Depression

Sleep disturbances are considered an underlying neurobiological mechanism of depression, a condition deemed a leading nonfatal cause of disability by the World Health Organisation. Approximately 50 to 70 million adults in the United States suffer from a sleep disorder, and 40% of all patients with insomnia have a coexisting psychiatric condition.

Ketamine edges out ECT for refractory depression

Graphic illustration of person with depression with clouds over their head

Ketamine is gaining ground to replace electroconvulsive therapy and the safer, more effective treatment for refractory depression. A single “ketamine infusion showed similar probability of suicidal ideation reduction as a full course of ECT”   Electroconvulsive therapy and ketamine both work well for refractory depression, but ketamine had the edge in a small, open label […]