What’s The Difference Between Ketamine & Spravato?

What’s The Difference Between Ketamine & Spravato?

In recent years, ketamine and Spravato (esketamine) have emerged as groundbreaking treatments for various mental health conditions. Both medications offer hope for individuals who have not found relief with traditional treatments. But what sets ketamine and Spravato apart? Let’s find out.

Understanding Ketamine & Spravato

Ketamine is an FDA-approved anesthetic medication that has recently gained recognition for its off-label use in treating various mental health conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD), especially when other treatments have failed. Ketamine infusions have also proven to be highly effective in managing chronic pain.

On the other hand, Spravato is a nasal spray formulation of esketamine, a derivative of ketamine. It is an FDA-approved medication specifically developed for the treatment of treatment-resistant depression (TRD). Being a derivative of ketamine, Spravato shares a lot of similarities with ketamine, including the mode of action and potential side effects.

Exploring The Differences Between Ketamine & Spravato

Mode Of Administration

Ketamine: Ketamine is mainly administered intravenously (IV) in small controlled doses, meaning it is delivered directly into the bloodstream through an IV line – hence the name ketamine infusion therapy. IV ketamine treatments are typically conducted in a clinic or medical setting, allowing for precise dosage control and monitoring by healthcare professionals. Ketamine infusion therapy usually involves a series of treatments over several weeks.

Spravato: Spravato, on the other hand, is self-administered as a nasal spray under the supervision of a healthcare professional. It provides a convenient and non-invasive option compared to IV administration.

Treatment Setting & Frequency

Ketamine: As mentioned, ketamine infusions are typically administered in a doctor’s office or clinic setting, and the patient is closely monitored by qualified healthcare professionals for any adverse reactions. A single infusion session lasts between 40 minutes to 1 hour, and the number and frequency of ketamine infusions needed may vary depending on individual needs and response to treatment.

Spravato: Spravato is self-administered once or twice weekly in a doctor’s office under professional supervision. The treatment is often followed by a two-hour observation period to ensure any temporary side effects, such as increased blood pressure, dissociation, and sedation, have subsided before the patient is discharged.

FDA Approval Status

Ketamine: Ketamine has been used safely for over five decades as an FDA-approved anesthetic. However, it was not until recently that researchers discovered its remarkable efficacy in treating various mental and physical health conditions. And although ketamine infusion therapy is yet to receive FDA approval, its off-label use as an experimental medication is widely practiced and with remarkable success.

Spravato: Spravato received FDA approval in 2019, specifically for treatment-resistant depression. It is typically prescribed as an adjunctive therapy, meaning it must be used alongside oral antidepressants for optimal results.

Treatment Versatility

Ketamine: Although ketamine infusion therapy is primarily known for its use in treating depression and anxiety disorders, it has also shown great promise in managing chronic pain, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), substance use disorders, and bipolar disorder.

Spravato: Spravato is FDA-approved specifically for treatment-resistant depression, and major depression with suicidal ideation.

Final Thoughts

Ketamine and Spravato represent breakthrough treatments for individuals struggling with treatment-resistant mental disorders. While ketamine has been used off-label for years with remarkable success, Spravato offers a more accessible and regulated option. The choice between ketamine and Spravato depends on various factors, including individual treatment goals, preferences, and medical considerations.

At Revitalizing Infusion Therapies, we offer a range of cutting-edge treatments, including Spravato and ketamine infusion therapy, to help those struggling with hard-to-treat psychiatric disorders find reprieve.

If you are interested in learning more about ketamine for treatment in Kissimmee, FL, contact Revitalizing Infusion Therapies and request your consultation today.


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